A photo of a person sniffing a bottle of nail polish remover, surrounded by scientific books and brain-shaped balloons, emphasizing the question of whether it harms brain cells.

Does Smelling Nail Polish Remover Kill Brain Cells?

The strong scent of nail polish remover, with its harsh acetone odor, makes many people wonder: Is inhaling the fumes from this common beauty product damaging my brain cells?

If you’re short on time, here’s a quick answer to your question: While occasional, minor inhalation may be fine, intentionally breathing in large amounts of nail polish remover fumes over time can potentially cause harm to the brain by destroying neuron cells and reducing cognitive function.

But small, incidental exposure through normal use is unlikely to kill significant brain cells.

In this approximately 3000-word article, we’ll provide an in-depth look at whether exposure to nail polish remover can kill brain cells. We’ll examine the chemical components of nail polish remover, analyze research on acetone and other solvents’ effects on the brain, explore conditions like sudden sniffing death syndrome, differentiate potential damage between incidental and repeated deliberate inhalation, compare its effects to other inhaled chemicals like glue or gasoline fumes, look at other health consequences such as organ damage, and provide recommendations for safer use.

The Chemical Components of Nail Polish Remover


Acetone is the primary solvent used in most nail polish removers. It is an effective solvent that breaks down the nail polish and removes it from the nail plate. However, acetone is also a harsh chemical that can dry out the skin and nails with repeated exposure.

This amazing solvent makes removing nail polish easy, but it should be used moderately.

Acrylic monomers

Some nail polish removers also contain acrylic monomers like ethyl methacrylate. These chemicals help moisturize and condition the nails and skin after exposure to drying solvents like acetone. Using removers with acrylic monomers may help prevent cracked and peeling nails over time.

Kudos to chemistry for creating formulas that remove nail polish efficiently while caring for our nails!

Fragrance ingredients

Many nail polish removers contain added fragrances to mask the strong odor of chemicals like acetone. Common fragrance ingredients include floral essential oils, fruit extracts, and synthetic musk. Smelling fruity nail polish remover likely won’t kill brain cells, but some sensitive individuals may experience headaches or allergic reactions to the fragrance components.

Seek fragrance-free options if you experience negative reactions.

How the Inhalation of Nail Polish Remover Affects the Brain

Destruction of brain cells and tissue

Inhaling nail polish remover fumes can be extremely damaging to the brain due to the chemicals present. The main concerning ingredient is toluene, which can cause brain cell death and irreversible brain damage with repeated exposure.

According to research from the National Center for Biotechnology Information, toluene destroys brain tissue in regions like the cerebral cortex, cerebellum and brain stem.

Specifically, toluene affects glial cells in the brain, which help provide nutrients and oxygen to neurons. When these cells are damaged, neurons start to die off. Over time, widespread death of brain cells occurs, leading to decreased brain size and impaired functioning.

Impaired cognitive function and memory loss

In addition to structural brain damage, inhaling solvents like nail polish remover causes issues with thinking, information processing and memory retrieval. According to the Recovery Village, cognitive deficits from toluene abuse include:

  • Difficulty with learning and concentration
  • Impaired speech and language capabilities
  • Inability to solve complex problems
  • Loss of memory and amnesia
  • Permanent IQ loss

These effects occur because solvents like toluene alter neurotransmitter levels and interfere with signaling between brain cells. Cognitive impairment from nail polish remover sniffing can range from mild to disabling, depending on the duration and intensity of abuse.

Risk of sudden sniffing death syndrome

The most serious risk from inhaling volatile solvents like nail polish remover is sudden death. This is known as “sudden sniffing death syndrome” and it is estimated to cause around 100-200 deaths per year in the U.S. alone, as cited by the Recovery Village.

The mechanism behind sudden sniffing death is erratic heart rhythms from solvent abuse. Specifically, chemicals like toluene sensitize the heart to adrenaline. This can trigger arrhythmias, cardiac arrest and death, even after just one session of solvent huffing.

Deaths typically occur from ventricular fibrillation or asystole, where the heart stops beating completely. Many cases happen without warning, giving no chance for life-saving intervention. Overall, the risk of sudden death further highlights the dangers of recreational inhalant use.

The Extent of Damage Depends on Exposure Level

Brief exposure from normal usage is likely harmless

Inhaling small amounts of nail polish remover during routine manicures or pedicures is unlikely to cause brain damage, according to experts. Nail polish remover contains chemicals like acetone, ethyl acetate, and butyl acetate which can be hazardous in large doses.

However, the brief exposures from nail salon visits or painting your own nails at home provide only minor inhalation.

A CDC report on acetone exposure stated that acute toxicity from inhalation requires exceedingly high levels rarely encountered outside industrial accidents. The minor exposures from using nail polish remover as directed for its intended purpose is generally considered safe.

Research on industrial workers regularly exposed to acetone also showed no lasting effects on brain health. For most people using nail polish remover in ventilated rooms for manicures, potential harm seems minimal.

Repeated deliberate inhalation poses high risks

Inhaling concentrated fumes from nail polish remover or other household chemicals to get high can severely impact the brain and body, however.

Intentionally breathing in nail polish remover vapors directly from a bottle or soaked rag can result in extremely high chemical levels in the bloodstream. This floods the brain with toxins, potentially killing brain cells and connections.

According to neurologists, permanent brain damage from inhalant abuse can include:

  • Impaired cognition, memory loss, lower IQ
  • Speech and hearing problems
  • Loss of coordination, motor control issues
  • Personality changes, depression, aggression

Additionally, high concentrations of inhalants may cause heart failure or lethal heart rhythm problems in the moment. Sudden sniffing death from using household chemicals to get high is tragically common among teens.

Number of annual ER visits from inhalant abuse (U.S.): Around 20,000
Percentage resulting in death: Up to 5%

While regulated nail salon exposure seems relatively low-risk, no level of recreational inhalant abuse should be considered safe. The brain damage, organ failure, and sudden death risks are far too severe. Parents should safeguard chemicals and talk about these dangers with teens.

Comparison to Other Inhaled Substances and Risks

Stronger effects than glue or markers

Inhaling nail polish remover fumes can have stronger mind-altering effects compared to sniffing other common household products like glue or permanent markers. This is because the main ingredient in nail polish remover, acetone, is a harsh solvent that quickly enters the bloodstream when inhaled.

Acetone vapors act as a depressant on the central nervous system, producing effects like dizziness, lack of coordination, and slurred speech within seconds of inhalation.

In contrast, glue and markers contain less potent solvents like toluene, xylene, and n-hexane. While they can also cause intoxication when inhaled in excess, their effects tend to be milder compared to acetone.

According to studies, the intoxicating effects of nail polish remover can be detected after just 2-3 breaths, whereas a higher volume of glue or marker fumes is required to produce similar effects.

Less dangerous than gasoline or paint thinner fumes

Though nail polish remover can get you high fast, inhaling its vapors is less likely to be fatal compared to sniffing other heavy-duty solvents like gasoline or paint thinner.

Gasoline is made up of highly volatile hydrocarbons and can quickly cause oxygen deprivation when inhaled intentionally. Just a few breaths of concentrated gasoline vapors can cause sudden sniffing death due to heart failure.

Paint thinner contains solvents like toluene, xylene, and methanol which are also extremely toxic when inhaled directly.

In comparison, the acetone in nail polish remover is less lethal in low doses. However, long-term abuse of nail polish remover can still lead to lasting neurological damage. According to the NIH, chronic inhalant abuse kills around 100 people each year in the U.S.

So while less immediately dangerous than gasoline or paint thinner fumes, nail polish remover should still always be used cautiously as directed.

Other Health Risks of Nail Polish Remover Inhalation

Gastrointestinal problems

Inhaling nail polish remover fumes can lead to irritation and inflammation of the gastrointestinal tract (source). Some common GI problems include:

  • Nausea and vomiting – The chemicals in nail polish remover can stimulate the vomiting center in the brain.
  • Abdominal pain and diarrhea – Inflammation of the stomach and intestines can cause cramping, pain, and diarrhea.
  • Decreased appetite – Severe exposures can cause a loss of appetite due to GI irritation.

These GI effects may be temporary or long-lasting depending on the extent of exposure. According to one study, around 18% of people hospitalized for nail polish remover poisoning had lasting GI problems (source).

Liver and kidney damage

The ingredients in nail polish remover like acetone and ethyl acetate can also be toxic to the liver and kidneys with repeated high exposures (source). This can lead to:

  • Abnormal liver enzyme tests indicating liver injury
  • Decreased kidney function and even kidney failure in severe cases
Liver Problems 18%
Kidney Problems 9%

According to a case series, the rates of liver and kidney complications among those hospitalized for nail polish remover poisoning were as shown (source). The good news is most cases resolved with treatment and without permanent damage.

Recommendations for Safe Use of Nail Polish Remover

Using nail polish remover regularly can expose you to potentially harmful chemicals. However, you can take steps to use it safely and minimize any risks.

Choose Safer Formulas

Traditional nail polish removers contain chemicals like acetone, ethyl acetate, and propyl acetate which can be drying and irritating with excessive use. Instead, look for “non-acetone” or “acetone-free” nail polish removers, which substitute gentler ingredients like methyl soyate.

You can also find removers made with nourishing oils like vitamin E, sunflower oil, and coconut oil to counteract the drying effects.

Use Sparingly

To limit exposure, only use nail polish remover as needed when redoing your manicure. Soak a cotton ball and avoid excessive rubbing. Never inhale directly from the bottle. Follow the usage instructions carefully and never exceed the recommended amounts.

Work in a Well-Ventilated Space

The potent fumes from chemicals in traditional nail polish removers can be harmful if inhaled regularly or in large amounts. Always use remover in a room with open windows or doors to allow for airflow. Avoid small enclosed spaces like bathrooms.

Consider using a small desktop fan to improve ventilation.

Moisturize After Use

Acetone and other chemicals in remover can dry and irritate the skin and nails with repeated use. Apply a moisturizing cream after removing polish, focusing on the nails and cuticles. Look for moisturizers with nourishing oils and butters. You can also apply a hydrating cuticle oil.

Consider Protective Gloves

Wearing gloves limits direct contact between the remover and your skin. Opt for disposable gloves made of vinyl, nitrile or latex. Reusable cotton gloves also provide a protective barrier. Just be sure to launder them frequently.

Never Inhale or Drink

Inhaling or consuming nail polish remover is extremely dangerous and can be fatal. Never put remover in your mouth or intentionally breathe in the fumes. Keep bottles tightly sealed and out of reach of children. Contact emergency services immediately if ingestion occurs.

Using nail polish remover with caution can help reduce any risks. Focus on safer formulas, proper ventilation, and moisturizing after use. Avoid misuse and you can safely incorporate remover into your manicure routine.


While using nail polish remover as intended poses little risk of brain cell damage, intentionally inhaling concentrated fumes can destroy neurons, reduce brain function, and potentially even kill immediately.

To avoid toxicity, use nail polish remover only for its intended purpose, never deliberately breathe in its fumes, work in a well-ventilated area, limit exposure time, and watch for symptoms of overexposure like dizziness or headaches.

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